Mieloblastin
(Preusmjereno sa stranice PMNL proteinaza)
Mieloblastin (EC 3.4.21.76, leukocitna proteinaza 3, leukocitna proteinaza 4, Vegenerov granulomatozni autoantigen, proteinaza PR-3, proteinaza-3, PMNL proteinaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Mieloblastin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.76 | ||||||||
| CAS broj | 128028-50-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Ovaj enzim je prisutan u polimorfonuklearnim leukocitnim granulama.
Reference
uredi- ↑ Labbaye, C., Musette, P. and Cayre, Y.E. (1991). „Wegener autoantigen and myeloblastin are encoded by a single mRNA”. Proc. Natl. Acad. Sci. USA 88: 9253-9256. PMID 1681549.
- ↑ Rao, N.V., Wehner, N.G., Marshall, B.C., Gray, W.R., Gray, B.H. and Hoidal, J.R. (1991). „Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties”. J. Biol. Chem. 266: 9540-9548. PMID 2033050.
- ↑ Brubaker, M.J., Groutas, W.C., Hoidal, J.R. and Rao, N.V. (1992). „Human neutrophil proteinase 3: mapping of the substrate binding site using peptidyl thiobenzyl esters”. Biochem. Biophys. Res. Commun. 188: 1318-1324. PMID 1445363.
- ↑ Kam, C.-M., Kerrigan, J.E., Dolman, K.M., Goldschmeding, R., von dem Borne, A.E.G.K. and Powers, J.C. (1992). „Substrate and inhibitor studies on proteinase 3”. FEBS Lett. 297: 119-123. PMID 1551417.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.