(6-4)DNK fotolijaza
(Preusmjereno sa stranice PL-(6-4))
(6-4)DNK fotolijaza (EC 4.1.99.13, DNK fotolijaza, H64PRH, NF-10, phr (6-4), PL-(6-4), OtCPF1, (6-4) PHR, At64PHR) je enzim sa sistematskim imenom (6-4) fotoprodukt pirimidin-lijaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| (6-4)DNK fotolijaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.1.99.13 | ||||||||
| CAS broj | 37290-70-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (6-4) fotoprodukt (u DNK) 2 pirimidinski ostaci (u DNK)
Ovaj enzim je flavoprotein (FAD).
Reference
uredi- ↑ Hitomi, K., DiTacchio, L., Arvai, A.S., Yamamoto, J., Kim, S.T., Todo, T., Tainer, J.A., Iwai, S., Panda, S. and Getzoff, E.D. (2009). „Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes”. Proc. Natl. Acad. Sci. USA 106: 6962-6967. PMID 19359474.
- ↑ Schleicher, E., Hitomi, K., Kay, C.W., Getzoff, E.D., Todo, T. and Weber, S. (2007). „Electron nuclear double resonance differentiates complementary roles for active site histidines in (6-4) photolyase”. J. Biol. Chem. 282: 4738-4747. PMID 17164245.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.