CGMP-zavisna proteinska kinaza
(Preusmjereno sa stranice PKG 1beta)
CGMP-zavisna proteinska kinaza (EC 2.7.11.12, 3':5'-ciklična GMP-zavisna proteinska kinaza, cGMP-zavisna proteinska kinaza Ibeta, guanozin 3':5'-ciklični monofosfat-zavisna proteinska kinaza, PKG, PKG 1alfa, PKG 1beta, PKG II, STK23) je enzim sa sistematskim imenom ATP:protein fosfotransferaza (cGMP-zavisni).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| CGMP-zavisna proteinska kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 2.7.11.12 | ||||||||
| CAS broj | 141588-27-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ATP + protein ADP + fosfoprotein
CGMP je neophodan za aktivaciju enzima.
Reference
uredi- ↑ Gill, G.N., Holdy, K.E., Walton, G.M. and Kanstein, C.B. (1976). „Purification and characterization of 3′:5′-cyclic GMP-dependent protein kinase”. Proc. Natl. Acad. Sci. USA 73: 3918-3922. PMID 186778.
- ↑ Murthy, K.S. (2004). „Modulation of soluble guanylate cyclase activity by phosphorylation”. Neurochem. Int. 45: 845-851. PMID 15312978.
- ↑ Richie-Jannetta, R., Francis, S.H. and Corbin, J.D. (2003). „Dimerization of cGMP-dependent protein kinase Iβ is mediated by an extensive amino-terminal leucine zipper motif, and dimerization modulates enzyme function”. J. Biol. Chem. 278: 50070-50079. PMID 12933804.
- ↑ Zhao, J., Trewhella, J., Corbin, J., Francis, S., Mitchell, R., Brushia, R. and Walsh, D. (1997). „Progressive cyclic nucleotide-induced conformational changes in the cGMP-dependent protein kinase studied by small angle X-ray scattering in solution”. J. Biol. Chem. 272: 31929-31936. PMID 9395542.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.