PFKP
(Preusmjereno sa stranice PFKF)
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Fosfofruktokinaza, trombocit, takođe poznata kao PFKP je enzim koji je kod ljudi kodiran PFKP genom.[1]
| Fosfofruktokinaza, trombocit | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | PFKP; ATP-PFK; PFK-C; PFK-P; PFKF | ||||||||||
| Vanjski ID | OMIM: 171840 MGI: 1891833 HomoloGene: 20579 GeneCards: PFKP Gene | ||||||||||
| EC broj | 2.7.1.11 | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 5214 | 56421 | |||||||||
| Ensembl | ENSG00000067057 | ENSMUSG00000021196 | |||||||||
| UniProt | Q01813 | Q9WUA3 | |||||||||
| Ref. Sekv. (iRNK) | NM_001242339 | NM_001291071 | |||||||||
| Ref. Sekv. (protein) | NP_001229268 | NP_001278000 | |||||||||
| Lokacija (UCSC) | Chr 10: 3.11 - 3.18 Mb | Chr 13: 6.58 - 6.65 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Funkcija
urediPFKP gen kodira trombocitnu izoformu fosfofruktokinaze (PFK) (ATP:D-fruktoza-6-fosfat-1-fosfotransferaza, EC 2.7.1.11). PFK katalizujue ireverzibilnu konverziju fruktoza 6-fosfata do fruktoza 1,6-bisfosfata i ključni je regulatorni enzim u glikolizi. PFKP gen, koji je mapiran na hromozomu 10p, je isto tako izražen u fibroblastima. Mišićna (PFKM) i jetrena (PFKL) izoforma fosfofruktokinaze su locirane na hromozomima 12q13 i 21q22, respektivno. Completni tetramerni fosfofruktokinazni enzim koji je prisutan u trombocitima može da bude formiran od podjedinica P4, P3L, i P2L2.[2][1]
Reference
uredi- ↑ 1,0 1,1 „Entrez Gene: PFKP phosphofructokinase, platelet”.
- ↑ Vora S (April 1981). „Isozymes of human phosphofructokinase in blood cells and cultured cell lines: molecular and genetic evidence for a trigenic system”. Blood 57 (4): 724–32. PMID 6451249.
Literatura
uredi- Meienhofer MC, Lagrange JL, Cottreau D i dr.. (1979). „Phosphofructokinase in human blood cells”. Blood 54 (2): 389–400. PMID 156568.
- Kahn A, Meienhofer MC, Cottreau D i dr.. (1979). „Phosphofructokinase (PFK) isozymes in man. I. Studies of adult human tissues”. Hum. Genet. 48 (1): 93–108. DOI:10.1007/bf00273280. PMID 156693.
- Morrison N, Simpson C, Fothergill-Gilmore L i dr.. (1992). „Regional chromosomal assignment of the human platelet phosphofructokinase gene to 10p15”. Hum. Genet. 89 (1): 105–6. DOI:10.1007/BF00207053. PMID 1533608.
- Simpson CJ, Fothergill-Gilmore LA (1991). „Isolation and sequence of a cDNA encoding human platelet phosphofructokinase”. Biochem. Biophys. Res. Commun. 180 (1): 197–203. DOI:10.1016/S0006-291X(05)81276-8. PMID 1834056.
- Nakajima H, Noguchi T, Yamasaki T i dr.. (1987). „Cloning of human muscle phosphofructokinase cDNA”. FEBS Lett. 223 (1): 113–6. DOI:10.1016/0014-5793(87)80519-7. PMID 2822475.
- Eto K, Sakura H, Yasuda K i dr.. (1994). „Cloning of a complete protein-coding sequence of human platelet-type phosphofructokinase isozyme from pancreatic islet”. Biochem. Biophys. Res. Commun. 198 (3): 990–8. DOI:10.1006/bbrc.1994.1141. PMID 8117307.
- Bonaldo MF, Lennon G, Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Res. 6 (9): 791–806. DOI:10.1101/gr.6.9.791. PMID 8889548.
- Adam GC, Sorensen EJ, Cravatt BF (2003). „Trifunctional chemical probes for the consolidated detection and identification of enzyme activities from complex proteomes”. Mol. Cell Proteomics 1 (10): 828–35. DOI:10.1074/mcp.T200007-MCP200. PMID 12438565.
- Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T i dr.. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
- Navarro-Lérida I, Martínez Moreno M, Roncal F i dr.. (2004). „Proteomic identification of brain proteins that interact with dynein light chain LC8”. Proteomics 4 (2): 339–46. DOI:10.1002/pmic.200300528. PMID 14760703.
- Beausoleil SA, Jedrychowski M, Schwartz D i dr.. (2004). „Large-scale characterization of HeLa cell nuclear phosphoproteins”. Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. DOI:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA i dr.. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rush J, Moritz A, Lee KA i dr.. (2005). „Immunoaffinity profiling of tyrosine phosphorylation in cancer cells”. Nat. Biotechnol. 23 (1): 94–101. DOI:10.1038/nbt1046. PMID 15592455.
- Hannemann A, Jandrig B, Gaunitz F i dr.. (2005). „Characterization of the human P-type 6-phosphofructo-1-kinase gene promoter in neural cell lines”. Gene 345 (2): 237–47. DOI:10.1016/j.gene.2004.11.018. PMID 15716112.
- Beausoleil SA, Villén J, Gerber SA i dr.. (2006). „A probability-based approach for high-throughput protein phosphorylation analysis and site localization”. Nat. Biotechnol. 24 (10): 1285–92. DOI:10.1038/nbt1240. PMID 16964243.
- Ewing RM, Chu P, Elisma F i dr.. (2007). „Large-scale mapping of human protein–protein interactions by mass spectrometry”. Mol. Syst. Biol. 3 (1): 89. DOI:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- Martínez-Costa OH, Sánchez-Martínez C, Sánchez V, Aragón JJ (2007). „Chimeric phosphofructokinases involving exchange of the N- and C-terminal halves of mammalian isozymes: implications for ligand binding sites”. FEBS Lett. 581 (16): 3033–8. DOI:10.1016/j.febslet.2007.05.059. PMID 17544406.