PFKL

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6-Fosfofruktokinaza, jetreni tip je enzim koji je kod ljudi kodiran PFKL genom.

Fosfofruktokinaza, jetra
Identifikatori
Simboli	PFKL; ATP-PFK; PFK-B; PFK-L
Vanjski ID	OMIM: 171860 MGI: 97547 HomoloGene: 55668 GeneCards: PFKL Gene
EC broj	2.7.1.11
Ontologija gena Molekulska funkcija • 6-fosfofruktokinazna aktivnost • proteinsko vezivanje • ATP vezivanje Ćelijska komponenta • citosol • 6-fosfofruktokinazni kompleks • membrana Biološki proces • ugljenohidratni metabolički proces • fruktoza 6-fosfatni metabolički proces • glukozni metabolički proces
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	5211	18641
Ensembl	ENSG00000141959	ENSMUSG00000020277
UniProt	P17858	P12382
Ref. Sekv. (iRNK)	NM_001002021	NM_008826
Ref. Sekv. (protein)	NP_001002021	NP_032852
Lokacija (UCSC)	Chr 21: 45.72 - 45.75 Mb	Chr 10: 77.99 - 78.01 Mb
PubMed pretraga	[1]	[2]

Fosfofruktokinaza (PFK) je tetramerni enzim koji katalizuje ključni korak u glikolizi, konverziju D-fruktoze 6-fosfata do D-fruktoze 1,6-bisfosfata. Zasebni genei kodiraju mišićnu podjedinicu (M) i jetrenu podjedinicu (L). PFK iz mišića je homotetramer M podjedinica, PFK iz jetre je homotetramer L-jedinica, dok se PFK iz trombocita može sastojati od bilo koje tetramerne kombinacije M i L podjedinica. Protein kodiran ovim genom je L podjedinica. Dve transkriptne varijante koje kodiraju različite izoforme su poznate.

Literatura

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