3-Ketovalidoksilaminska C-N-lijaza
(Preusmjereno sa stranice P-nitrophenyl-3-ketovalidamine p-nitroaniline lyase)
3-Ketovalidoksilaminska C-N-lijaza (EC 4.3.3.1, 3-ketovalidoksilamin A C-N-lijaza, p-nitrofenil-3-ketovalidamin p-nitroanilin lijaza, 4-nitrofenil-3-ketovalidamin 4-nitroanilin-lijaza) je enzim sa sistematskim imenom 4-nitrofenil-3-ketovalidamin 4-nitroanilin-lijaza (formira 5-D-(5/6)-5-C-(hidroksimetil)-2,6-dihidroksicikloheks-2-en-1).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 3-Ketovalidoksilaminska C-N-lijaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.3.3.1 | ||||||||
| CAS broj | 99889-98-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 4-nitrofenil-3-ketovalidamin 4-nitroanilin + 5-D-(5/6)-5-C-(hidroksimetil)-2,6-dihidroksiciklohex-2-en-1-on
Za dejstvo ovog enzima je neophodan jon Ca2+.
Reference uredi
- ↑ Asano, N., Takeuchi, M., Ninomiya, K., Kameda, Y. and Matsui, K. (1984). „Microbial degradation of validamycin A by Flavobacterium saccharophilum. Enzymatic cleavage of C-N linkage in validoxylamine A”. J. Antibiot. 37: 859-867. PMID 6548220.
- ↑ Takeuchi, M., Asano, N., Kameda, Y. and Matsui, K. (1985). „Purification and properties of 3-ketovalidoxylamine A C-N lyase from Flavobacterium saccharophilum”. J. Biochem. (Tokyo) 98: 1631-1638. PMID 4093450.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.