Aril-alkohol dehidrogenaza
(Preusmjereno sa stranice P-hydroxybenzyl alcohol dehydrogenase)
Aril-alkohol dehidrogenaza (EC 1.1.1.90, p-hidroksibenzil alkohol dehidrogenaza, benzil alkohol dehidrogenaza, koniferil alkohol dehidrogenaza) je enzim sa sistematskim imenom aril-alkohol:NAD+ oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Aril-alkohol dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.90 | ||||||||
| CAS broj | 37250-26-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- aromatični alkohol + NAD+ aromatični aldehid + NADH + H+
Ova grupa enzima ima široku specifičnost za primarne alkohole sa aromatičnim ili cikloheks-1-enskim prstenom. Oni imaju nisku aktivnosti ili nisu aktivni na kratkolačanim alifatičnim alkoholima.
Reference uredi
- ↑ Suhara, K., Takemori, S. and Katagiri, M. (1969). „The purification and properties of benzylalcohol dehydrogenase from Pseudomonas sp”. Arch. Biochem. Biophys. 130: 422-429. PMID 5778658.
- ↑ Yamanaka, K. and Minoshima, R. (1984). „Identification and characterization of a nicotinamide adenine dinucleotide-dependent para-hydroxybenzyl alcohol-dehydrogenase from Rhodopseudomonas acidophila M402”. Agric. Biol. Chem. 48: 1161-1171.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.