4-Hidroksibenzoat 3-monooksigenaza
(Preusmjereno sa stranice P-hydroxybenzoic acid hydroxylase)
4-hidroksibenzoat 3-monooksigenaza (EC 1.14.13.2, p-hidroksibenzoatna hidrolijaza, p-hidroksibenzoatna hidroksilaza, 4-hidroksibenzoatna 3-hidroksilaza, 4-hidroksibenzoatna monooksigenaza, 4-hidroksibenzoinska hidroksilaza, p-hidroksibenzoat-3-hidroksilaza, p-hidroksibenzojeva kiselina hidrolaza, p-hidroksibenzojeva hidroksilaza) je enzim sa sistematskim imenom 4-hidroksibenzoat,NADPH:kiseonik oksidoreduktaza (3-hidroksilacija).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
4-hidroksibenzoat 3-monooksigenaza | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifikatori | |||||||||
EC broj | 1.14.13.2 | ||||||||
CAS broj | 9059-23-8 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
|
- 4-hidroksibenzoat + NADPH + H+ + O2 protokatehuat + NADP+ + H2O
Ovaj enzim je flavoprotein (FAD). Većina enzima iz Pseudomonas su visoko specifični za NADPH (cf. EC 1.14.13.33, 4-hidroksibenzoat 3-monooksigenaza [NAD(P)H]).
Reference uredi
- ↑ Hosokawa, K. and Stanier, R.Y. (1966). „Crystallization and properties of p-hydroxybenzoate hydroxylase from Pseudomonas putida”. J. Biol. Chem. 241: 2453-2460. PMID 4380381.
- ↑ Howell, L.G., Spector, T. and Massey, V. (1972). „Purification and properties of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens”. J. Biol. Chem. 247: 4340-4350. PMID 4402514.
- ↑ Spector, T. and Massey, V. (1972). „Studies on the effector specificity of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens”. J. Biol. Chem. 247: 4679-4687. PMID 4402938.
- ↑ Spector, T. and Massey, V. (1972). „p-Hydroxybenzoate hydroxylase from Pseudomonas fluorescens. Evidence for an oxygenated flavin intermediate”. J. Biol. Chem. 247: 5632-5636. PMID 4403446.
- ↑ Spector, T. and Massey, V. (1972). „p-Hydroxybenzoate hydroxylase from Pseudomonas fluorescens. Reactivity with oxygen”. J. Biol. Chem. 247: 7123-7127. PMID 4404745.
- ↑ Seibold, B., Matthes, M., Eppink, M.H., Lingens, F., Van Berkel, W.J. and Muller, R. (1996). „4-Hydroxybenzoate hydroxylase from Pseudomonas sp. CBS3. Purification, characterization, gene cloning, sequence analysis and assignment of structural features determining the coenzyme specificity”. Eur. J. Biochem. 239: 469-478. PMID 8706756.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.