4-Hidroksibenzoat geraniltransferaza
(Preusmjereno sa stranice P-hydroxybenzoate geranyltransferase)
4-hidroksibenzoat geraniltransferaza (EC 2.5.1.93, PGT1, PGT2, 4HB geraniltransferaza, 4HB:geraniltransferaza, p-hidroksibenzoat geraniltransferaza, PHB geraniltransferaza, geranil difosfat:4-hidroksibenzoat geraniltransferaza) je enzim sa sistematskim imenom geranil-difosfat:4-hidroksibenzoat 3-geraniltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 4-hidroksibenzoat geraniltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.93 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- geranil difosfat + 4-hidroksibenzoat 3-geranil--4-hidroksibenzoat + difosfat
Ovaj enzim učestvuje u biosintezi šikonina.
Reference uredi
- ↑ Ohara, K., Muroya, A., Fukushima, N. and Yazaki, K. (2009). „Functional characterization of LePGT1, a membrane-bound prenyltransferase involved in the geranylation of p-hydroxybenzoic acid”. Biochem. J. 421: 231-241. PMID 19392660.
- ↑ Muhlenweg, A., Melzer, M., Li, S.M. and Heide, L. (1998). „4-Hydroxybenzoate 3-geranyltransferase from Lithospermum erythrorhizon: purification of a plant membrane-bound prenyltransferase”. Planta 205: 407-413. PMID 9640665.
- ↑ Yazaki, K., Kunihisa, M., Fujisaki, T. and Sato, F. (2002). „Geranyl diphosphate:4-hydroxybenzoate geranyltransferase from Lithospermum erythrorhizon. Cloning and characterization of a key enzyme in shikonin biosynthesis”. J. Biol. Chem. 277: 6240-6246. PMID 11744717.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.