4-Hidroksibenzoat nonapreniltransferaza
(Preusmjereno sa stranice P-hidroksibenzojeva-poliprenil transferaza)
4-Hidroksibenzoat nonapreniltransferaza (EC 2.5.1.39, nonaprenil-4-hidroksibenzoat transferaza, 4-hidroksibenzoat transferaza, p-hidroksibenzoat dimetilaliltransferaza, p-hidroksibenzoat polipreniltransferaza, p-hidroksibenzojeva kiselina-poliprenil transferaza, p-hidroksibenzojeva-poliprenil transferaza) je enzim sa sistematskim imenom poliprenil-difosfat:4-hidroksibenzoat polipreniltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 4-Hidroksibenzoat nonapreniltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.39 | ||||||||
| CAS broj | 9030-77-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- poliprenil difosfat + 4-hidroksibenzoat difosfat + 4-hidroksi-3-poliprenilbenzoat
Ovaj enzim učestvuje u biosintezi ubihinona.
Reference uredi
- ↑ Kalén, A., Appelkvist, E.-L., Chojnacki, T. and Dallner, G. (1990). „Nonaprenyl-4-hydroxybenzoate transferase, an enzyme involved in ubiquinone biosynthesis, in the endoplasmic reticulum-Golgi system of rat liver”. J. Biol. Chem. 265: 1158-1164. PMID 2295606.
- ↑ Melzer, M. and Heide, L. (1994). „Characterization of polyprenyldiphosphate: 4-hydroxybenzoate polyprenyltransferase from Escherichia coli”. Biochim. Biophys. Acta 1212: 93-102. PMID 8155731.
- ↑ Okada, K., Ohara, K., Yazaki, K., Nozaki, K., Uchida, N., Kawamukai, M., Nojiri, H. and Yamane, H. (2004). „The AtPPT1 gene encoding 4-hydroxybenzoate polyprenyl diphosphate transferase in ubiquinone biosynthesis is required for embryo development in Arabidopsis thaliana”. Plant Mol. Biol. 55: 567-577. PMID 15604701.
- ↑ Forsgren, M., Attersand, A., Lake, S., Grunler, J., Swiezewska, E., Dallner, G. and Climent, I. (2004). „Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ”. Biochem. J. 382: 519-526. PMID 15153069.
- ↑ Tran, U.C. and Clarke, C.F. (2007). „Endogenous synthesis of coenzyme Q in eukaryotes”. Mitochondrion 7 Suppl: S62-S71. PMID 17482885.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.