4-Krezol dehidrogenaza (hidroksilacija)
(Preusmjereno sa stranice P-cresol-(acceptor) oxidoreductase (hydroxylating))
4-krezol dehidrogenaza (hidroksilacija) (EC 1.17.99.1, p-krezol-(akceptor) oksidoreduktaza (hidroksilacija), p-krezol metilhidroksilaza) je enzim sa sistematskim imenom 4-metilfenol:akceptor oksidoreduktaza (metil-hidroksilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 4-krezol dehidrogenaza (hidroksilacija) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.17.99.1 | ||||||||
| CAS broj | 66772-07-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 4-metilfenol + akceptor + H2O 4-hidroksibenzaldehid + redukovani akceptor
Ovaj enzim je flavocitohrom c (FAD). Fenazin metosulfat može da deluje kao akceptor.
Reference uredi
- ↑ Hopper, D.J. and Taylor, D.G. (1977). „The purification and properties of p-cresol-(acceptor) oxidoreductase (hydroxylating), a flavocytochrome from Pseudomonas putida”. Biochem. J. 167: 155-162. PMID 588247.
- ↑ McIntire, W., Edmondson, D.E. and Singer, T.P. (1980). „8α-O-Tyrosyl-FAD: a new form of covalently bound flavin from p-cresol methylhydroxylase”. J. Biol. Chem. 255: 6553-6555. PMID 7391034.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.