Orotat reduktaza (NADPH)
Orotat reduktaza (NADPH) (EC 1.3.1.15, orotatna reduktaza, dihidro-orotska dehidrogenaza, L-5,6-dihidro-orotat:NAD+ oksidoreduktaza, orotatna reduktaza (NADPH)) je enzim sa sistematskim imenom (S)-dihidroorotat:NADP+ oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Orotat reduktaza (NADPH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.1.15 | ||||||||
| CAS broj | 37255-27-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (S)-dihidroorotat + NADP+ orotat + NADPH + H+
Ovaj enzim vezuje FMN i FAD. Druga klasa 1 dihidroorotatnih dehidrogenaza koristi bilo fumarat (EC 1.3.98.1) ili NAD+ (EC 1.3.1.14) kao elektronski akceptor. Membanska klasa 2 dihidroorotatnih dehidrogenaza (EC 1.3.5.2) koristi hinon kao elektronski akceptor .
Reference uredi
- ↑ Taylor, W.H., Taylor, M.L. and Eames, D.F. (1966). „Two functionally different dihydroorotic dehydrogenases in bacteria”. J. Bacteriol. 91: 2251-2256. PMID 4380263.
- ↑ Udaka, S. and Vennesland, B. (1962). „Properties of triphosphopyridine nucleotide-linked dihydroorotic dehydrogenase”. J. Biol. Chem. 237: 2018-2024. PMID 13923427.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.