Oktanoil-(GcvH):protein N-oktanoiltransferaza
Oktanoil-(GcvH):protein N-oktanoiltransferaza (EC 2.3.1.204, LIPL, oktanoil-(GcvH):E2 amidotransferaza, YWFL (gen)) je enzim sa sistematskim imenom (sistem H odvajanja glicina)-N6-oktanoil-L-lizin:(lipoil-nosilac protein)-N6-L-lizin oktanoiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Oktanoil-(GcvH):protein N-oktanoiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.204 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- [sistem H odvajanja glicina]-N6-oktanoil-L-lizin + [lipoil-nosilac protein] sistem H odvajanja glicina + [lipoil-nosilac protein]-N6-oktanoil-L-lizin
Kod bakterije Bacillus subtilis ovaj enzim katalizuje amidotransfer oktanoilne grupe sa [sistem H za odvajanje glicina]-N6-oktanoil-L-lizina (i.e. oktanoil-GcvH) na E2 podjednicu (dihidrolipoamid acetiltransferazu) piruvatne dehidrogenaze.
Reference uredi
- ↑ Christensen, Q.H., Martin, N., Mansilla, M.C., de Mendoza, D. and Cronan, J.E. (2011). „A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis”. Mol. Microbiol. 80: 350-363. PMID 21338421.
- ↑ Martin, N., Christensen, Q.H., Mansilla, M.C., Cronan, J.E. and de Mendoza, D. (2011). „A novel two-gene requirement for the octanoyltransfer reaction of Bacillus subtilis lipoic acid biosynthesis”. Mol. Microbiol. 80: 335-349. PMID 21338420.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.