Orotidin-5'-fosfatna dekarboksilaza
(Preusmjereno sa stranice OMP-DC)
Orotidin-5'-fosfatna dekarboksilaza (EC 4.1.1.23, orotidin-5'-monofosfatna dekarboksilaza, orotodilatna dekarboksilaza, orotidin fosfatna dekarboksilaza, OMP dekarboksilaza, orotat monofosfatna dekarboksilaza, orotidin monofosfatna dekarboksilaza, orotidin fosfatna dekarboksilaza, OMP-DC, orotatska dekarboksilaza, orotidin 5'-fosfatna dekarboksilaza, orotidilna dekarboksilaza, orotidilno kiselinska dekarboksilaza, orotodilatna dekarboksilaza, ODCaza, orotinska dekarboksilaza, orotidin-5'-fosfatna karboksi-lijaza) je enzim sa sistematskim imenom orotidin-5'-fosfat karboksi-lijaza (formira UMP).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Orotidin-5'-fosfatna dekarboksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Identifikatori | |||||||||
| EC broj | 4.1.1.23 | ||||||||
| CAS broj | 9024-62-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- orotidin 5'-fosfat UMP + CO2
Ovaj enzim viših eukariota je identičan sa EC 2.4.2.10, orotat fosforiboziltransferazom.
Reference
uredi- ↑ Jones, M.E., Kavipurapu, P.R. and Traut, T.W. (1978). „Orotate phosphoribosyltransferase: orotidylate decarboxylase (Ehrlich ascites cell)”. Methods Enzymol. 51: 155-167. PMID 692383.
- ↑ Lieberman, I., Kornberg, A. and Simms, E.S. (1955). „Enzymatic synthesis of pyrimidine nucleotides. Orotidine-5′-phosphate and uridine-5′-phosphate”. J. Biol. Chem. 215: 403-415. PMID 14392174.
- ↑ McClard, R.W., Black, M.J., Livingstone, L.R. and Jones, M.E. (1980). „Isolation and initial characterization of the single polypeptide that synthesizes uridine 5′-monophosphate from orotate in Ehrlich ascites carcinoma. Purification by tandem affinity chromatography of uridine-5′-monophosphate synthase”. Biochemistry 19: 4699-4706. PMID 6893554.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.