O-fosfo-L-seril-tRNKSec:L-selenocisteinil-tRNK sintaza
(Preusmjereno sa stranice O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase)
O-fosfo-L-seril-tRNKSec:L-selenocisteinil-tRNK sintaza (EC 2.9.1.2, MMPSepSecS, SepSecS, SLA/LP, O-fosfoseril-tRNK:selenocisteinil-tRNK sintaza, O-fosfo-L-seril-tRNK:L-selenocisteinil-tRNK sintaza) je enzim sa sistematskim imenom selenofosfat:O-fosfo-L-seril-tRNKSec selenijum transferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| O-fosfo-L-seril-tRNKSec:L-selenocisteinil-tRNK sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Identifikatori | |||||||||
| EC broj | 2.9.1.2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- O-fosfo-L-seril-tRNKSec + selenofosfat L-selenocisteinil-tRNKSec + fosfat
Ovaj enzim je piridoksal-fosfatni protein.
Reference uredi
- ↑ Palioura, S., Sherrer, R.L., Steitz, T.A., Soll, D. and Simonovic, M. (2009). „The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation”. Science 325: 321-325. PMID 19608919.
- ↑ Araiso, Y., Palioura, S., Ishitani, R., Sherrer, R.L., O'Donoghue, P., Yuan, J., Oshikane, H., Domae, N., Defranco, J., Soll, D. and Nureki, O. (2008). „Structural insights into RNA-dependent eukaryal and archaeal selenocysteine formation”. Nucleic Acids Res. 36: 1187-1199. PMID 18158303.
- ↑ Aeby, E., Palioura, S., Pusnik, M., Marazzi, J., Lieberman, A., Ullu, E., Soll, D. and Schneider, A. (2009). „The canonical pathway for selenocysteine insertion is dispensable in Trypanosomes”. Proc. Natl. Acad. Sci. USA 106: 5088-5092. PMID 19279205.
- ↑ Yuan, J., Palioura, S., Salazar, J.C., Su, D., O'Donoghue, P., Hohn, M.J., Cardoso, A.M., Whitman, W.B. and Soll, D. (2006). „RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea”. Proc. Natl. Acad. Sci. USA 103: 18923-18927. PMID 17142313.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.