O-fosfoserin sulfhidrilaza
(Preusmjereno sa stranice O-phosphoserine sulfhydrylase)
O-fosfoserin sulfhidrilaza (EC 2.5.1.65, O-fosfoserin(tiol)-lijaza) je enzim sa sistematskim imenom O-fosfo-L-serin:vodonik-sulfid 2-amino-2-karboksietiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| O-fosfoserin sulfhidrilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.65 | ||||||||
| CAS broj | 1071505-11-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- O-fosfo-L-serin + vodonik sulfid L-cistein + fosfat
Ovaj enzim je piridoksal-fosfatni protein. Enzim iz Aeropyrum pernix deluje O-fosfo-L-serin i O3-acetil-L-serin, za razliku od enzima EC 2.5.1.47, cistein sintaze, koji deluje samo na O3-acetil-L-serin.
Reference uredi
- ↑ Mino, K. and Ishikawa, K. (2003). „A novel O-phospho-L-serine sulfhydrylation reaction catalyzed by O-acetylserine sulfhydrylase from Aeropyrum pernix K1”. FEBS Lett. 551: 133-138. PMID 12965218.
- ↑ Mino, K. and Ishikawa, K. (2003). „Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1”. J. Bacteriol. 185: 2277-2284. PMID 12644499.
- ↑ Mino, K. and Ishikawa, K. (2003). „Crystallization and preliminary X-ray diffraction analysis of O-acetylserine sulfhydrylase from Aeropyrum pernix K1”. Acta Crystallogr. D Biol. Crystallogr. 59: 338-340. PMID 12554945.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.