Acetilgalaktozaminil-O-glikozil-glikoprotein b-1,6-N-acetilglukozaminiltransferaza
(Preusmjereno sa stranice O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV)
Acetilgalaktozaminil-O-glikozil-glikoprotein b-1,6-N-acetilglukozaminiltransferaza (EC 2.4.1.148, O-glikozil-oligosaharid-glikoprotein N-acetilglukozaminiltransferaza IV, uridin difosfoacetilglukozamin-mucin beta(1->6)-acetilglukozaminiltransferaza B, UDP-N-acetil-D-glukozamin:O-oligosaharid-glikoprotein (N-acetil-D-glukozamin na N-acetil-D-galaktozamin - N-acetil-beta-D-glukozaminil-1,3-N-acetil-D-galaktozaminil-R) beta-1,6-N-acetil-D-glukozaminiltransferaza) je enzim sa sistematskim imenom UDP-N-acetil-D-glukozamin:N-acetil-beta-D-glukozaminil-(1->3)-N-acetil-D-galaktozaminil-R 6-beta-N-acetil-D-glukozaminiltransferaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Acetilgalaktozaminil-O-glikozil-glikoprotein b-1,6-N-acetilglukozaminiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.148 | ||||||||
| CAS broj | 95978-15-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- UDP-N-acetil-D-glukozamin + N-acetil-beta-D-glukozaminil-(1->3)-N-acetil-D-galaktozaminil-R UDP + N-acetil-beta-D-glukozaminil-(1->6)-[N-acetil-beta-D-glukozaminil-(1->3)]-N-acetil-D-galaktozaminil-R
Vidi još uredi
- EC 2.4.1.102 (beta-1,3-galaktozil-O-glikozil-glikoprotein beta-1,6-N-acetilglukozaminiltransferaza)
- EC 2.4.1.146 (beta-1,3-galaktozil-O-glikozil-glikoprotein beta-1,3-N-acetilglukozaminiltransferaza)
- EC 2.4.1.147 (acetilgalaktozaminil-O-glikozil-glikoprotein beta-1,3-N-acetilglukozaminiltransferaza)
Reference uredi
- ↑ Brockhausen, I., Rachaman, E.S., Matta, K.L. and Schachter, H. (1983). „The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis”. Carbohydr. Res. 120: 3-16. PMID 6226356.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.