B-1,3-galaktozil-O-glikozil-glikoprotein b-1,6-N-acetilglukozaminiltransferaza

B-1,3-galaktozil-O-glikozil-glikoprotein b-1,6-N-acetilglukozaminiltransferaza
Identifikatori
EC broj	2.4.1.102
CAS broj	95978-15-7
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

B-1,3-galaktozil-O-glikozil-glikoprotein b-1,6-N-acetilglukozaminiltransferaza (EC 2.4.1.102, O-glikozil-oligosaharid-glikoprotein N-acetilglukozaminiltransferaza I, beta6-N-acetilglukozaminiltransferaza, uridin difosfoacetilglukozamin-mucin beta-(1->6)-acetilglukozaminiltransferaza, jezgro 2 acetilglukozaminiltransferaza, jezgro 6-beta-GlcNAc-transferaza A, UDP-N-acetil-D-glukozamin:O-glikozil-glikoprotein (N-acetil-D-glukozamin za N-acetil-D-galaktozamina beta-D-galaktozil-1,3-N-acetil-D-galaktozaminil-R) beta-1,6-N-acetil-D-glukozaminiltransferaza) je enzim sa sistematskim imenom UDP-N-acetil-D-glukozamin:O-glikosil-glikoprotein (N-acetil-D-glukozamin to N-acetil-D-galaktozamin of beta-D-galaktozil-(1->3)-N-acetil-D-galaktozaminil-R) 6-beta-N-acetil-D-glukozaminiltransferaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-N-acetil-D-glukozamin + beta-D-galaktozil-(1->3)-N-acetil-D-galaktozaminil-R

\rightleftharpoons

UDP + beta-D-galaktozil-(1->3)-[N-acetil-beta-D-glukozaminil-(1->6)]-N-acetil-D-galaktozaminil-R

Reference uredi

↑ Brockhausen, I., Rachaman, E.S., Matta, K.L. and Schachter, H. (1983). „The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis”. Carbohydr. Res. 120: 3-16. PMID 6226356.
↑ Williams, D., Longmore, G., Matta, K.L. and Schachter, H. (1980). „Mucin synthesis. II. Substrate specificity and product identification studies on canine submaxillary gland UDP-GlcNAc:Gal β1-3GalNAc(GlcNAc→GalNAc) β6-N-acetylglucosaminyltransferase”. J. Biol. Chem. 255: 11253-11261. PMID 6449508.
↑ Williams, D. and Schachter, H. (1980). „Mucin synthesis. I. Detection in canine submaxillary glands of an N-acetylglucosaminyltransferase which acts on mucin substrates”. J. Biol. Chem. 255: 11247-11252. PMID 6449507.

Literatura uredi

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vidi još uredi

EC 2.4.1.146 (beta-1,3-galaktozil-O-glikozil-glikoprotein beta-1,3-N-acetilglukozaminiltransferaza)
EC 2.4.1.147 (acetilgalaktozaminil-O-glikozil-glikoprotein beta-1,3-N-acetilglukozaminiltransferaza)
EC 2.4.1.148 (acetilgalaktozaminil-O-glikozil-glikoprotein beta-1,6-N-acetilglukozaminiltransferaza)

Vanjske veze uredi

MeSH Beta-1,3-galactosyl-O-glycosyl-glycoprotein+beta-1,6-N-acetylglucosaminyltransferase

[1] Brockhausen, I., Rachaman, E.S., Matta, K.L. and Schachter, H. (1983). „The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis”. Carbohydr. Res. 120: 3-16. PMID 6226356.

[2] Williams, D., Longmore, G., Matta, K.L. and Schachter, H. (1980). „Mucin synthesis. II. Substrate specificity and product identification studies on canine submaxillary gland UDP-GlcNAc:Gal β1-3GalNAc(GlcNAc→GalNAc) β6-N-acetylglucosaminyltransferase”. J. Biol. Chem. 255: 11253-11261. PMID 6449508.

[3] Williams, D. and Schachter, H. (1980). „Mucin synthesis. I. Detection in canine submaxillary glands of an N-acetylglucosaminyltransferase which acts on mucin substrates”. J. Biol. Chem. 255: 11247-11252. PMID 6449507.

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