Fosfoserin transaminaza
(Preusmjereno sa stranice O-fosfo-L-serin:2-oksoglutarat aminotransferaza)
Fosfoserin transaminaza (EC 2.6.1.52, PSAT, fosfoserinska aminotransferaza, 3-fosfoserinska aminotransferaza, hidroksipiruvinski fosfat-glutaminska transaminaza, L-fosfoserinska aminotransferaza, fosfohidroksipiruvatna transaminaza, fosfohidroksipiruvinska-glutamatna transaminaza, 3-O-fosfo-L-serin:2-oksoglutaratna aminotransferaza, SerC, PdxC, 3PHP transaminaza) je enzim sa sistematskim imenom O-fosfo-L-serin:2-oksoglutarat aminotransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Fosfoserin transaminaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.6.1.52 | ||||||||
| CAS broj | 9030-90-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (1) O-fosfo-L-serin + 2-oksoglutarat 3-fosfonooksipiruvat + L-glutamat
- (2) 4-fosfonooksi-L-treonin + 2-oksoglutarat (3R)-3-hidroksi-2-okso-4-fosfonooksibutanoat + L-glutamat
Ovaj enzim je piridoksal-fosfatni protein. Ovaj enzim katalizuje drugi korak serinske biosinteze kod Escherichia coli.
Reference uredi
- ↑ Hirsch, H. and Greenberg, D.M. (1967). „Studies on phosphoserine aminotransferase of sheep brain”. J. Biol. Chem. 242: 2283-2287. PMID 6022873.
- ↑ Pizer, L.I. (1963). „The pathway and control of serine biosynthesis in Escherichia coli”. J. Biol. Chem. 238: 3934-3944. PMID 14086727.
- ↑ Zhao, G. and Winkler, M.E. (1996). „A novel α-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria”. J. Bacteriol. 178: 232-239. PMID 8550422.
- ↑ Drewke, C., Klein, M., Clade, D., Arenz, A., Müller, R. and Leistner, E. (1996). „4-O-phosphoryl-L-threonine, a substrate of the pdxC(serC) gene product involved in vitamin B6 biosynthesis”. FEBS Lett. 390: 179-182. PMID 8706854.
- ↑ Zhao, G. and Winkler, M.E. (1996). „4-Phospho-hydroxy-L-threonine is an obligatory intermediate in pyridoxal 5′-phosphate coenzyme biosynthesis in Escherichia coli K-12”. FEMS Microbiol. Lett. 135: 275-280. PMID 8595869.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.