O-fosfo-L-seril-tRNK:Cys-tRNK sintaza
(Preusmjereno sa stranice O-fosfo-L-seril-tRNK:Cys-tRNK-sintaza)
O-fosfo-L-seril-tRNK:Cys-tRNK sintaza (EC 2.5.1.73, SepCysS, Sep-tRNK:Cys-tRNK sintaza) je enzim sa sistematskim imenom O-fosfo-L-seril-tRNKCis:vodonik sulfid 2-aminopropanoat transferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| O-fosfo-L-seril-tRNK:Cys-tRNK sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.73 | ||||||||
| CAS broj | 1239229-21-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
U organizmima poput Archaeoglobus fulgidus kojima nedostaje enzim EC 6.1.1.16 (cistein---tRNK ligaza) za direktno formiranje Cys-tRNKCys, taj molekul se indirektno obrazuje posredstvom enzima EC 6.1.1.27 (O-fosfoseril-tRNK ligaze) koja ligira O-fosfoserin do tRNKCys, i EC 2.5.1.73, koji konvertuje nastali O-fosfo-L-seril-tRNKCys do Cys-tRNKCys.
Reference uredi
- ↑ Fukunaga, R. and Yokoyama, S. (2007). „Structural insights into the second step of RNA-dependent cysteine biosynthesis in archaea: crystal structure of Sep-tRNA:Cys-tRNA synthase from Archaeoglobus fulgidus”. J. Mol. Biol. 370: 128-141. PMID 17512006.
- ↑ Hauenstein, S.I. and Perona, J.J. (2008). „Redundant synthesis of cysteinyl-tRNACys in Methanosarcina mazei”. J. Biol. Chem. 283: 22007-22017. PMID 18559341.
- ↑ Yuan, J., Palioura, S., Salazar, J.C., Su, D., O'Donoghue, P., Hohn, M.J., Cardoso, A.M., Whitman, W.B. and Soll, D. (2006). „RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea”. Proc. Natl. Acad. Sci. USA 103: 18923-18927. PMID 17142313.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.