Nitrilna hidrataza
Nitrilna hidrataza (EC 4.2.1.84, 3-cijanopiridinska hidrataza, NHaza, L-NHaza, H-NHaza, akrilonitrilna hidrataza, alifatična nitrilna hidrataza, nitrilna hidrolijaza) je enzim sa sistematskim imenom alifatični-amid hidrolijaza (formira nitril).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Nitrilna hidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 4.2.1.84 | ||||||||
| CAS broj | 82391-37-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- alifatični amid nitril + H2O
Ovaj enzim deluje na kratkolančane alifatične nitrile.
Reference
uredi- ↑ Asano, Y., Fujishiro, K., Tani, Y. and Yamada, H. (1982). „Microbial degradation of nitrile compounds. 5. Aliphatic nitrile hydratase from Arthrobacter sp J-1. Purification and characterization”. Agric. Biol. Chem. 46: 1165-1174.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.