Nitrilaza
Nitrilaza (EC 3.5.5.1, acetonitrilaza, benzonitrilaza) je enzim sa sistematskim imenom nitril aminohidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Nitrilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| Identifikatori | |||||||||
| EC broj | 3.5.5.1 | ||||||||
| CAS broj | 9024-90-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- nitril + 2H2O karboksilat + NH3
Ovaj enzim deluje na širok opseg aromatičnih nitrila.
Reference uredi
- ↑ Harper, D.B. (1977). „Microbial metabolism of aromatic nitriles. Enzymology of C-N cleavage by Nocardia sp. (rhodochrous group) N.C.I.B. 11216”. Biochem. J. 165: 309-319. PMID 21655.
- ↑ Thimann, K.V. and Mahadevan, S. (1964). „Nitrilase. I. Occurrence, preparation, and general properties of the enzyme”. Arch. Biochem. Biophys. 105: 133-141. PMID 14165487.
- ↑ Pace, H.C. and Brenner, C. (2001). „The nitrilase superfamily: classification, structure and function”. Genome Biol. 2: 0001.-001.9. PMID 11380987.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.