8-Okso-dGDP fosfataza
(Preusmjereno sa stranice NUDT5)
8-Okso-dGDP fosfataza (EC 3.6.1.58, NUDT5) je enzim sa sistematskim imenom 8-okso-dGDP fosfohidrolaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 8-Okso-dGDP fosfataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.6.1.58 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 8-okso-dGDP + H2O 8-okso-dGMP + fosfat
Ovaj enzim katalizuje hidrolizu 8-okso-dGDP i 8-okso-GDP.
Reference uredi
- ↑ Ishibashi, T., Hayakawa, H., Ito, R., Miyazawa, M., Yamagata, Y. and Sekiguchi, M. (2005). „Mammalian enzymes for preventing transcriptional errors caused by oxidative damage”. Nucleic Acids Res. 33: 3779-3784. PMID 16002790.
- ↑ Ishibashi, T., Hayakawa, H. and Sekiguchi, M. (2003). „A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides”. EMBO Rep. 4: 479-483. PMID 12717453.
- ↑ Kamiya, H., Hori, M., Arimori, T., Sekiguchi, M., Yamagata, Y. and Harashima, H. (2009). „NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity”. DNA Repair (Amst) 8: 1250-1254. PMID 19699693.
- ↑ Ito, R., Sekiguchi, M., Setoyama, D., Nakatsu, Y., Yamagata, Y. and Hayakawa, H. (2011). „Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein”. J. Biochem. 149: 731-738. PMID 21389046.
- ↑ Zha, M., Zhong, C., Peng, Y., Hu, H. and Ding, J. (2006). „Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity”. J. Mol. Biol. 364: 1021-1033. PMID 17052728.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.