Dezoksicitidin kinaza
(Preusmjereno sa stranice NTP:deoxycytidine 5'-phosphotransferase)
Dezoksicitidin kinaza (EC 2.7.1.74, dezoksicitidinska kinaza (fosforilacija), 2'-dezoksicitidinska kinaza, Ara-C kinaza, arabinofuranozilcitozinska kinaza, dezoksicitidin-citidinska kinaza) je enzim sa sistematskim imenom NTP:dezoksicitidin 5'-fosfotransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Dezoksicitidin kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 2.7.1.74 | ||||||||
| CAS broj | 9039-45-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- NTP + dezoksicitidin NDP + dCMP
Citozin arabinozid može da deluje kao akceptor. Svi prirodni nukleozid trifosfati (izuzev dCTP) mogu da budu donori.
Reference uredi
- ↑ Durham, J.P. and Ives, D.H. (1970). „Deoxycytidine kinase. II. Purification and general properties of the calf thymus enzyme”. J. Biol. Chem. 245: 2276-2284. PMID 5442271.
- ↑ Ives, D.H. and Durham, J.P. (1970). „Deoxycytidine kinase. 3. Kinetics and allosteric regulation of the calf thymus enzyme”. J. Biol. Chem. 245: 2285-2294. PMID 5462538.
- ↑ Kessel, D. (1968). „Properties of deoxycytidine kinase partially purified from L1210 cells”. J. Biol. Chem. 243: 4739-4744. PMID 5687717.
- ↑ Momparler, R.L. and Fischer, G.A. (1968). „Mammalian deoxynucleoside kinase. I. Deoxycytidine kinase: purification, properties, and kinetic studies with cytosine arabinoside”. J. Biol. Chem. 243: 4298-4304. PMID 5684726.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.