Flavivirin
(Preusmjereno sa stranice NS2B-3 proteinase)
Flavivirin (EC 3.4.21.91, proteaza virusa žute groznice (flavi virusa), NS2B-3 proteinaza) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Flavivirin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.91 | ||||||||
| CAS broj | 154215-26-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Selectivna hidroliza -Xaa-Xaa-Yaa- veza u kojima Xaa može da bude bilo Arg ili Lys i Yaa može da bude bilo Ser ili Ala
Ovaj enzim je poznat iz klasičnih flavivirusa (žuta groznica, denga groznica).
Reference uredi
- ↑ Chambers, T.J., Hahn, C.S., Galler, R. and Rice, C.M. (1990). „Flavivirus genome organization, expression, and replication”. Annu. Rev. Microbiol. 44: 649-688. PMID 2174669.
- ↑ Cahour, A., Falgout, B. and Lai, C.-J. (1992). „Cleavage of the dengue virus polyprotein at the NS3/NS4A and NS4B/NS5 junctions is mediated by viral protease NS2B-NS3, whereas NS4A/NS4B may be processed by a cellular protease”. J. Virol. 66: 1535-1542. PMID 1531368.
- ↑ Lin, C., Amberg, S.M., Chambers, T.J. and Rice, C.M. (1993). „Cleavage at a novel site in the NS4A region by the yellow fever virus NS2B-3 proteinase is a prerequisite for processing at the downstream 4A/4B signalase site”. J. Virol. 67: 2327-2335. PMID 8445732.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.