Saharoza sintaza
(Preusmjereno sa stranice NDP-glukoza:D-fruktoza 2-alfa-D-glukoziltransferaza)
Saharoza sintaza (EC 2.4.1.13, UDPglukoza-fruktoza glukoziltransferaza, saharozna sintetaza, saharoza-UDP glukoziltransferaza, saharoza-uridin difosfatna glukoziltransferaza, uridin difosfoglukoza-fruktozna glukoziltransferaza) je enzim sa sistematskim imenom NDP-glukoza:D-fruktoza 2-alfa-D-glukoziltransferaza.[1][2][3][4][5][6][7][8][9][10] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Saharoza sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 2.4.1.13 | ||||||||
| CAS broj | 2604301 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Mada se UDP generalno smatra preferentnim nukleozid difosfatom za sintezu saharoze, brojne studije su pokazale da ADP isto tako može da bude efektivan akceptor.
Reference uredi
- ↑ Avigad, G. and Milner, Y. (1966). „UDP-glucose:fructose transglucosylase from sugar beet roots”. Methods Enzymol. 8: 341-345.
- ↑ Cardini, C.E., Leloir, L.F. and Chiriboga, J. (1955). „The biosynthesis of sucrose”. J. Biol. Chem. 214: 149-155. PMID 14367373.
- ↑ Delmer, D.P. (1972). „The purification and properties of sucrose synthetase from etiolated Phaseolus aureus' seedlings”. J. Biol. Chem. 247: 3822-3828. PMID 4624446.
- ↑ Murata, T., Sugiyama, T., Minamikawa, T. and Akazawa, T. (1966). „Enzymic mechanism of starch synthesis in ripening rice grains. Mechanism of the sucrose-starch conversion”. Arch. Biochem. Biophys. 113: 34-44. PMID 5941994.
- ↑ Nakai, T., Konishi, T., Zhang, X.-Q., Chollet, R., Tonouchi, N., Tsuchida, T., Yoshinaga, F., Mori, H., Sakai, F. and Hayashi, T. (1998). „An increase in apparent affinity for sucrose of mung bean sucrose synthase is caused by in vitro phosphorylation or directed mutagenesis of Ser11”. Plant Cell Physiol. 39: 1337-1341. PMID 10050318.
- ↑ Porchia, A.C., Curatti, L. and Salerno, G.L. (1999). „Sucrose metabolism in cyanobacteria: sucrose synthase from Anabaena sp. strain PCC 7119 is remarkably different from the plant enzymes with respect to substrate affinity and amino-terminal sequence”. Planta 210: 34-40. PMID 10592030.
- ↑ Ross, H.A. and Davies, H.V. (1992). „Purification and characterization of sucrose synthase from the cotyledons of Vicia fava L”. Plant Physiol. 100: 1008-1013. PMID 16653008.
- ↑ Silvius, J.E. and Snyder, F.W. (1979). „Comparative enzymic studies of sucrose metabolism in the taproots and fibrous roots of Beta vulgaris L”. Plant Physiol. 64: 1070-1073. PMID 16661094.
- ↑ Tanase, K. and Yamaki, S. (2000). „Purification and characterization of two sucrose synthase isoforms from Japanese pear fruit”. Plant Cell Physiol. 41: 408-414. PMID 10845453.
- ↑ Baroja-Fernández, E., Muñnoz, F.J., Saikusa, T., Rodríguez-López, M., Akazawa, T. and Pozueta-Romero, J. (2003). „Sucrose synthase catalyzes the de novo production of ADPglucose linked to starch biosynthesis in heterotrophic tissues of plants”. Plant Cell Physiol. 44: 500-509. PMID 12773636.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.