N8-acetilspermidin oksidaza (formira propan-1,3-diamin)
N8-acetilspermidin oksidaza (formira propan-1,3-diamin) (EC 1.5.3.15, N8-acetilspermidinska oksidaza (formira propan-1,3-diamin)) je enzim sa sistematskim imenom N8-acetilspermidin:kiseonik oksidoreduktaza (formira propan-1,3-diamin).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| N8-acetilspermidin oksidaza (formira propan-1,3-diamin) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.5.3.15 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- N8-acetilspermidin + O2 +H2O propan-1,3-diamin + 4-acetamidobutanal +H2O2
Ovaj enzim je takođe aktivan na N1-acetilsperminu. On u maloj meri deluje na N1,N12-diacetilspermin.
Reference
uredi- ↑ Shukla, O.P., Muller, S. and Walter, R.D. (1992). „Polyamine oxidase from Acanthamoeba culbertsoni specific for N8-acetylspermidine”. Mol. Biochem. Parasitol. 51: 91-98. PMID 1565141.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.