N-acetilornitin karbamoiltransferaza
N-acetilornitin karbamoiltransferaza (EC 2.1.3.9, acetilornitinska transkarbamilaza, N-acetilornitinska transkarbamilaza, AOTC, karbamoil-fosfat:2-N-acetil-L-ornitinska karbamoiltransferaza, AOTCaza) je enzim sa sistematskim imenom karbamoil-fosfat:N2-acetil-L-ornitin karbamoiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| N-acetilornitin karbamoiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.3.9 | ||||||||
| CAS broj | 890853-54-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- karbamoil fosfat + N2-acetil-L-ornitin fosfat + N-acetil-L-citrulin
Ovaj enzim se razlikuje od EC 2.1.3.3, ornitin karbamoiltransferaze.
Reference uredi
- ↑ Shi, D., Morizono, H., Yu, X., Roth, L., Caldovic, L., Allewell, N.M., Malamy, M.H. and Tuchman, M. (2005). „Crystal structure of N-acetylornithine transcarbamylase from Xanthomonas campestris: a novel enzyme in a new arginine biosynthetic pathway found in several Eubacteria”. J. Biol. Chem. 280: 14366-14369. PMID 15731101.
- ↑ Morizono, H., Cabrera-Luque, J., Shi, D., Gallegos, R., Yamaguchi, S., Yu, X., Allewell, N.M., Malamy, M.H. and Tuchman, M. (2006). „Acetylornithine transcarbamylase: a novel enzyme in arginine biosynthesis”. J. Bacteriol. 188: 2974-2982. PMID 16585758.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.