Metansulfonat monooksigenaza
(Preusmjereno sa stranice MsmABC)
Metansulfonat monooksigenaza (EC 1.14.13.111, mesilatna monooksigenaza, mesilat,redukovani-FMN:kiseonik oksidoreduktaza, MsmABC, metansulfonska kiselina monooksigenaza, MSA monooksigenaza, MSAMO) je enzim sa sistematskim imenom metansulfonat,NADH:kiseonik oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Metansulfonat monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.111 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- metansulfonat + NADH + H+ + O2 formaldehid + NAD+ + sulfit + H2O
Ovaj enzim je flavoprotein. Metansulfonat je najjednostavniji sulfonat i supstrat za rast pojedinih metilotrofnih mikroorganizama.
Reference uredi
- ↑ de Marco, P., Moradas-Ferreira, P., Higgins, T.P., McDonald, I., Kenna, E.M. and Murrell, J.C. (1999). „Molecular analysis of a novel methanesulfonic acid monooxygenase from the methylotroph Methylosulfonomonas methylovora”. J. Bacteriol. 181: 2244-2251. PMID 10094704.
- ↑ Higgins, T.P., Davey, M., Trickett, J., Kelly, D.P. and Murrell, J.C. (1996). „Metabolism of methanesulfonic acid involves a multicomponent monooxygenase enzyme”. Microbiology 142: 251-260. PMID 8932698.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.