Monoterpen epsilon-laktonska hidrolaza
Monoterpen epsilon-laktonska hidrolaza (EC 3.1.1.83, MLH) je enzim sa sistematskim imenom izoprop(en)ilmetiloksepan-2-on laktonohidrolaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Monoterpen epsilon-laktonska hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.1.83 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (1) izoprop(en)ilmetiloksepan-2-on + H2O 6-hidroksiizoprop(en)ilmetilheksanoat (generalna reakcija)
- (2) 4-izopropenil--7-metiloksepan-2-on + H2O 6-hidroksi-3-izopropenilheptanoat
- (3) 7-izopropil-4-metiloksepan-2-on + H2O 6-hidroksi-3,7-dimetiloktanoat
Ovaj enzim katalizuje otvaranje prstena epsilon-laktona koji se formira tokom degradacije dihidrokarveola u Gram-pozitivnoj bakteriji Rhodococcus eritropolis DCL14.
Reference uredi
- ↑ van der Vlugt-Bergmans , C.J. and van der Werf , M.J. (2001). „Genetic and biochemical characterization of a novel monoterpene ε-lactone hydrolase from Rhodococcus erythropolis DCL14”. Appl. Environ. Microbiol. 67: 733-741. PMID 11157238.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.