Monofenol monooksigenaza
Monofenol monooksigenaza (EC 1.14.18.1, fenolaza, monofenol oksidaza, krezolaza, monofenolaza, tirozin-dopa oksidaza, monofenolna monooksidaza, monofenol dihidroksifenilalanin:kiseonik oksidoreduktaza, N-acetil-6-hidroksitriptofan oksidaza, monofenol, dihidroksi-L-fenilalanin kiseonik oksidoreduktaza, o-difenol:O2 oksidoreduktaza, fenol oksidaza) je enzim sa sistematskim imenom L-tirozin,L-dopa:kiseonik oksidoreduktaza.[1][2][3][4][5][6][7][8][9][10][11][12] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Monofenol monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.18.1 | ||||||||
| CAS broj | 2594228 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (1) L-tirozin + O2 dopahinon + H2O (sveukupna reakcija)
- (1a) L-tirozin + 1/2 O2 L-dopa
- (1b) L-dopa + 1/2 O2 dopahinon +H2O
- (2) 2 L-dopa + O2 2 dopahinon + 2H2O
Ovaj enzim je tip III bakarni protein prisutan u širokom varijetetu bakterija, gljiva, biljki, insekata, rakova i sisara. On učestvuje u sintezi betalaina i melanina.
Reference uredi
- ↑ Dawson, C.R. and Tarpley, W.B. (1951). „The copper oxidases”. u: Sumner, J.B. and Myrbäck, K.. The Enzymes. 2 (1st izd.). New York: Academic Press. str. 454-498.
- ↑ Patil, S.S. and Zucker, M. (1965). „Potato phenolases. Purification and properties”. J. Biol. Chem. 240: 3938-3943. PMID 5842066.
- ↑ Pomerantz, S.H. (1963). „Separation, purification, and properties of two tyrosinases from hamster melanoma”. J. Biol. Chem. 238: 2351-2357. PMID 13972077.
- ↑ Pomerantz, S.H. (1963). „Separation, purification, and properties of two tyrosinases from hamster melanoma”. J. Biol. Chem. 238: 2351-2357. PMID 13972077.
- ↑ Robb, D.A. (1984). „`Tyrosinase”. u: Lontie, R.. Copper Proteins and Copper Enzymes. 2. Boca Raton, FL: CRC Press. str. 207-240.
- ↑ Robb, D.A. (1984). „`Tyrosinase”. u: Lontie, R.. Copper Proteins and Copper Enzymes. 2. Boca Raton, FL: CRC Press. str. 207-240.
- ↑ Sanchez-Ferrer, A., Rodriguez-Lopez, J.N., Garcia-Canovas, F. and Garcia-Carmona, F. (1995). „Tyrosinase: a comprehensive review of its mechanism”. Biochim. Biophys. Acta 1247: 1-11. PMID 7873577.
- ↑ Sanchez-Ferrer, A., Rodriguez-Lopez, J.N., Garcia-Canovas, F. and Garcia-Carmona, F. (1995). „Tyrosinase: a comprehensive review of its mechanism”. Biochim. Biophys. Acta 1247: 1-11. PMID 7873577.
- ↑ Steiner, U., Schliemann, W. and Strack, D. (1996). „Assay for tyrosine hydroxylation activity of tyrosinase from betalain-forming plants and cell cultures”. Anal. Biochem. 238: 72-75. PMID 8660589.
- ↑ Steiner, U., Schliemann, W. and Strack, D. (1996). „Assay for tyrosine hydroxylation activity of tyrosinase from betalain-forming plants and cell cultures”. Anal. Biochem. 238: 72-75. PMID 8660589.
- ↑ Rolff, M., Schottenheim, J., Decker, H. and Tuczek, F. (2011). „Copper-O2 reactivity of tyrosinase models towards external monophenolic substrates: molecular mechanism and comparison with the enzyme”. Chem Soc Rev 40: 4077-4098. PMID 21416076.
- ↑ Rolff, M., Schottenheim, J., Decker, H. and Tuczek, F. (2011). „Copper-O2 reactivity of tyrosinase models towards external monophenolic substrates: molecular mechanism and comparison with the enzyme”. Chem Soc Rev 40: 4077-4098. PMID 21416076.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Robb, D.A. (1984). „`Tyrosinase”. u: Lontie, R.. Copper Proteins and Copper Enzymes. 2. Boca Raton, FL: CRC Press. str. 207-240.
- Robb, D.A. (1984). „`Tyrosinase”. u: Lontie, R.. Copper Proteins and Copper Enzymes. 2. Boca Raton, FL: CRC Press. str. 207-240.
- Dawson, C.R. and Tarpley, W.B. (1951). „The copper oxidases”. u: Sumner, J.B. and Myrbäck, K.. The Enzymes. 2 (1st izd.). New York: Academic Press. str. 454-498.