Molibdopterin molibdotransferaza
Molibdopterin molibdotransferaza (EC 2.10.1.1, MoeA, Cnx1) je enzim sa sistematskim imenom adenilil-molibdopterin:molibdat molibdat transferaza (formira AMP).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Molibdopterin molibdotransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.10.1.1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- adenilil-molibdopterin + molibdat molibdenski kofaktor + AMP
Ovaj enzim katalizuje umetanje molibdena u en-ditiol grupu molibdopterina.
Reference uredi
- ↑ Nichols, J.D. and Rajagopalan, K.V. (2005). „In vitro molybdenum ligation to molybdopterin using purified components”. J. Biol. Chem. 280: 7817-7822. PMID 15632135.
- ↑ Nichols, J.D., Xiang, S., Schindelin, H. and Rajagopalan, K.V. (2007). „Mutational analysis of Escherichia coli MoeA: two functional activities map to the active site cleft”. Biochemistry 46: 78-86. PMID 17198377.
- ↑ Llamas, A., Otte, T., Multhaup, G., Mendel, R.R. and Schwarz, G. (2006). „The Mechanism of nucleotide-assisted molybdenum insertion into molybdopterin. A novel route toward metal cofactor assembly”. J. Biol. Chem. 281: 18343-18350. PMID 16636046.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.