Mn2+ zavisna ADP-ribozna/CDP-alkoholna difosfataza
(Preusmjereno sa stranice Mn2+-zavisna ADP-riboza/CDP-alkohol pirofosfataza)
Mn2+ zavisna ADP-ribozna/CDP-alkoholna difosfataza (EC 3.6.1.53, Mn2+-zavisna ADP-riboza/CDP-alkohol pirofosfataza, ADPRibaza-Mn) je enzim sa sistematskim imenom CDP-holin fosfohidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Mn2+ zavisna ADP-ribozna/CDP-alkoholna difosfataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.6.1.53 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (1) CDP-holin + H2O CMP + fosfoholin
- (2) ADP-riboza + H2O AMP + D-riboza 5-fosfat
Za dejstvo ovog enzima je neophodan jon Mn2+.
Reference uredi
- ↑ Canales, J., Pinto, R.M., Costas, M.J., Hernández, M.T., Miró, A., Bernet, D., Fernández, A. and Cameselle, J.C. (1995). „Rat liver nucleoside diphosphosugar or diphosphoalcohol pyrophosphatases different from nucleotide pyrophosphatase or phosphodiesterase I: substrate specificities of Mg2+-and/or Mn2+-dependent hydrolases acting on ADP-ribose”. Biochim. Biophys. Acta 1246: 167-177. PMID 7819284.
- ↑ Canales, J., Fernández, A., Ribeiro, J.M., Cabezas, A., Rodrigues, J.R., Cameselle, J.C. and Costas, M.J. (2008). „Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells”. Biochem. J. 413: 103-113. PMID 18352857.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.