Mevaldat reduktaza (NADPH)
Mevaldat reduktaza (NADPH) (EC 1.1.1.33, mevaldat (redukovani nikotinamid adenin dinukleotid fosfat) reduktaza) je enzim sa sistematskim imenom (R)-mevalonat:NADP+ oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Mevaldat reduktaza (NADPH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.33 | ||||||||
| CAS broj | 9028-34-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- (R)-mevalonat + NADP+ mevaldat + NADPH + H+
Dva supstrata ovog enzima su (R)-mevalonat i NADP+, dok su njegova 3 produkta: mevaldat, NADPH, i H+.
Reference
uredi- ↑ Coon, M.J., Kupiecki, F.P., Dekker, E.E., Schlesinger, M.J. and del Campillo, A. (1959). „The enzymic synthesis of branched-chain acids”. u: Wolstenholme, G.E.W. and O'Connor, M.. CIBA Symposium on the Biosynthesis of Terpenes and Sterols. London: CIBA Symposium on the Biosynthesis of Terpenes and Sterols. str. 62-74.
- ↑ von Wartburg, J.P. and Wermoth, B. (1980). „Aldehyde reductase”. u: Jakoby, W.B.. Enzymatic Basis of Detoxication. 1. New York: Academic Press. str. 249-260.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.