Metiltioribuloza 1-fosfatna dehidrataza
Metiltioribuloza 1-fosfatna dehidrataza (EC 4.2.1.109, 1-PMT-ribuloza dehidrataza, S-metil-5-tio-D-ribuloza-1-fosfat hidrolijaza) je enzim sa sistematskim imenom S-metil-5-tio-D-ribuloza-1-fosfat 4-hidrolijaza (formira 5-(metiltio)-2,3-dioksopentil-fosfat).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Metiltioribuloza 1-fosfatna dehidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.109 | ||||||||
| CAS broj | 1114239-22-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-metil-5-tio-D-ribuloza 1-fosfat 5-(metiltio)-2,3-dioksopentil fosfat + H2O
Ovaj enzim učestvuje u procesu spasavanja metionina.
Reference uredi
- ↑ Furfine, E.S. and Abeles, R.H. (1988). „Intermediates in the conversion of 5′-S-methylthioadenosine to methionine in Klebsiella pneumoniae”. J. Biol. Chem. 263: 9598-9606. PMID 2838472.
- ↑ Wray, J.W. and Abeles, R.H. (1995). „The methionine salvage pathway in Klebsiella pneumoniae and rat liver. Identification and characterization of two novel dioxygenases”. J. Biol. Chem. 270: 3147-3153. PMID 7852397.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.