Metilmalonil-KoA dekarboksilaza
Metilmalonil-KoA dekarboksilaza (EC 4.1.1.41, propionil koenzim A karboksilaza, metilmalonil-koenzim A dekarboksilaza, (S)-2-metil-3-oksopropanoil-KoA karboksilijaza, (S)-metilmalonil-KoA karboksilijaza) je enzim sa sistematskim imenom (S)-metilmalonil-KoA karboksilijaza (formira propanoil-KoA).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Metilmalonil-KoA dekarboksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Trimer metilmalonil-KoA dekarboksilaze (E. coli) | |||||||||
| Identifikatori | |||||||||
| EC broj | 4.1.1.41 | ||||||||
| CAS broj | 37289-44-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- (S)-metilmalonil-KoA propanoil-KoA + CO2
Enzim iz Veillonella alcalescens je biotinski protein.
Reference
uredi- ↑ Galivan, J.H. and Allen, S.H.G. (1968). „Methylmalonyl coenzyme A decarboxylase. Its role in succinate decarboxylation by Micrococcus lactilyticus”. J. Biol. Chem. 243: 1253-1261. PMID 5646172.
- ↑ Hilpert, W. and Dimroth, P. (1982). „Conversion of the chemical energy of methylmalonyl-CoA decarboxylation into a Na+ gradient”. Nature 296: 584-585. PMID 7070502.
- ↑ Hoffmann, A., Hilpert, W. and Dimroth, P. (1989). „The carboxyltransferase activity of the sodium-ion-translocating methylmalonyl-CoA decarboxylase of Veillonella alcalescens”. Eur. J. Biochem. 179: 645-650. PMID 2920730.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.