Metilendiureja deaminaza
Metilendiureja deaminaza (EC 3.5.3.21, metilindiurejaza) je enzim sa sistematskim imenom metilindiureja aminohidrolaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Metilendiureja deaminaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.5.3.21 | ||||||||
| CAS broj | 205830-62-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- metilindiureja + 2H2O N-(hidroksimetil)ureja + 2 NH3 + CO2 (sveukupna reakcija)
- (1a) metilindiureja + H2O N-(karboksiaminometil)ureja + NH3
- (1b) N-(karboksiaminometil)ureja N-(aminometil)ureja + CO2 (spontana reakcija)
- (1c) N-(aminometil)ureja + H2O N-(hidroksimetil)ureja + NH3 (spontana reakcija)
Metilindiureja se hidrolizuje i dekarboksiluje čime se formira aminisana metilureja.
Reference uredi
- ↑ Jahns, T., Schepp, R., Kaltwasser, H. (1997). „Purification and characterisation of an enzyme from a strain of Ochrobactrum anthroπ that degrades condensation products of urea and formaldehyde (ureaform)”. Can. J. Microbiol. 43: 1111-1117.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.