Meteniltetrahidrofolat ciklohidrolaza
Meteniltetrahidrofolat ciklohidrolaza (EC 3.5.4.9, Citrovorum faktorska ciklodehidraza, ciklohidrolaza, formil-metenil-metilintetrahidrofolatna sintetaza (kombinovana)) je enzim sa sistematskim imenom 5,10-meteniltetrahidrofolat 5-hidrolaza (deciklizacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Meteniltetrahidrofolat ciklohidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.5.4.9 | ||||||||
| CAS broj | 9027-97-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 5,10-meteniltetrahidrofolat + H2O 10-formiltetrahidrofolat
Kod eukariota, ovaj enzim se javlja kao trifunkcionalni enzim koje je takođe metilintetrahidrofolatna dehidrogenaza (NADP+) (EC 1.5.1.5) i format-tetrahidrofolatna ligaza (EC 6.3.4.3).
Reference uredi
- ↑ Rabinowitz, J.C. and Pricer, W.E. (1956). „The enzymatic synthesis of N10-formyltetrahydrofolic acid and its role in ATP formation during formiminoglycine degradation”. J. Am. Chem. Soc. 78: 4176-4178.
- ↑ Tabor, H. and Wyngarden, L. (1959). „The enzymatic formation of formiminotetrahydrofolic acid, 5,10-methenyltetrahydrofolic acid, and 10-formyltetrahydrofolic acid in the metabolism of formiminoglutamic acid”. J. Biol. Chem. 234: 1830-1849. PMID 13672973.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.