Menahinol oksidaza (H+-transport)
Menahinol oksidaza (H+-transport) (EC 1.10.3.12, citohrom aa3-600 oksidaza, citohrom bd oksidaza) je enzim sa sistematskim imenom menahinol:O2 oksidoreduktaza (H+-transport).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Menahinol oksidaza (H+-transport) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.10.3.12 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2 menahinol + O2 2 menahinon + 2H2O
Citohrom aa3-600 je jedan od glavnih respiratornih oksidaza kod Bacillus subtilis. On je takođe član hem-bakar superfamilije kiseoničnih reduktaza, i blisko je homologan sa citohrom bo3 ubihinol oksidazom iz Escherichia coli, ali koristi menahinol umesto ubihinola kao supstrat.
Reference uredi
- ↑ Lauraeus, M. and Wikstrom, M. (1993). „The terminal quinol oxidases of Bacillus subtilis have different energy conservation properties”. J. Biol. Chem. 268: 11470-11473. PMID 8388393.
- ↑ Lemma, E., Simon, J., Schagger, H. and Kroger, A. (1995). „Properties of the menaquinol oxidase (Qox) and of qox deletion mutants of Bacillus subtilis”. Arch. Microbiol. 163: 432-438. PMID 7575098.
- ↑ Yi, S.M., Narasimhulu, K.V., Samoilova, R.I., Gennis, R.B. and Dikanov, S.A. (2010). „Characterization of the semiquinone radical stabilized by the cytochrome aa3-600 menaquinol oxidase of Bacillus subtilis”. J. Biol. Chem. 285: 18241-18251. PMID 20351111.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.