Dimetilglicin dehidrogenaza
(Preusmjereno sa stranice Me2GlyDH)
Dimetilglicin dehidrogenaza (EC 1.5.8.4, N,N-dimetilglicinska oksidaza, N,N-dimetilglicin:(akceptor) oksidoreduktaza (demetilacija), Me2GlyDH) je enzim sa sistematskim imenom N,N-dimetilglicin:elektron-transfer flavoprotein oksidoreduktaza (demetilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Dimetilglicin dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.5.8.4 | ||||||||
| CAS broj | 37256-30-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- N,N-dimetilglicin + elektron-transfer flavoprotein + H2O sarkozin + formaldehid + redukovani elektron-transfer flavoprotein
Ovaj enzim je flavoprotein. On sadrži histidil(N3)-(8alfa)FAD vezu.
Reference uredi
- ↑ Frisell, W.R. and MacKenzie, C.G. (1962). „Separation and purification of sarcosine dehydrogenase and dimethylglycine dehydrogenase”. J. Biol. Chem. 237: 94-98. PMID 13895406.
- ↑ Hoskins, D.D. and MacKenzie, C.G. (1961). „Solubilization and electron transfer flavoprotein requirement of mitochondrial sarcosine dehydrogenase and dimethylglycine dehydrogenase”. J. Biol. Chem. 236: 177-183. PMID 13716069.
- ↑ Brizio, C., Brandsch, R., Bufano, D., Pochini, L., Indiveri, C. and Barile, M. (2004). „Over-expression in Escherichia coli, functional characterization and refolding of rat dimethylglycine dehydrogenase”. Protein Expr. Purif. 37: 434-442. PMID 15358367.
- ↑ Brizio, C., Brandsch, R., Douka, M., Wait, R. and Barile, M. (2008). „The purified recombinant precursor of rat mitochondrial dimethylglycine dehydrogenase binds FAD via an autocatalytic reaction”. Int. J. Biol. Macromol. 42: 455-462. PMID 18423846.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.