Matični bromelain
Matični bromelain (EC 3.4.22.32, bromelain, ananasni matični bromelain) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Matični bromelain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.32 | ||||||||
| CAS broj | 37189-34-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Široka specifičnost za razlaganje proteina, sa jakom preferencijom za Z-Arg-Arg-NHMec
Ova cisteinska endopeptidaza je izobilno prisutna stabljici ananasne biljke, Ananas comosus.
Reference uredi
- ↑ Brocklehurst, K., Willenbrock, F. and Salih, E. (1987). „Cysteine proteinases”. u: Neuberger, A. and Brocklehurst, K.. New Comprehensive Biochemistry: Hydrolytic Enzymes. Amsterdam: Elsevier. str. 39-158.
- ↑ Rowan, A.D., Buttle, D.J. and Barrett, A.J. (1988). „Ananain: a novel cysteine proteinase found in pineapple stem”. Arch. Biochem. Biophys. 267: 262-270. PMID 3196029.
- ↑ Ritonja, A., Rowan, A.B., Buttle, D.J., Rawlings, N.D., Turk, V. and Barrett, A.J. (1989). „Stem bromelain: amino acid sequence and implications for weak binding to cystatin”. FEBS Lett. 247: 419-429. PMID 2714443.
- ↑ Rowan, A.D., Buttle, D.J. and Barrett, A.J. (1990). „The cysteine proteinases of the pineapple plant”. Biochem. J. 266: 869-875. PMID 2327970.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Brocklehurst, K., Willenbrock, F. and Salih, E. (1987). „Cysteine proteinases”. u: Neuberger, A. and Brocklehurst, K.. New Comprehensive Biochemistry: Hydrolytic Enzymes. Amsterdam: Elsevier. str. 39-158.