Teobromin sintaza
(Preusmjereno sa stranice MXMT)
Teobromin sintaza (EC 2.1.1.159, monometilksantinska metiltransferaza, MXMT, CTS1, CTS2, S-adenozil-L-metionin:7-metilksantin 3-N-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:7-metilksantin N3-metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Teobromin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.159 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozil-L-metionin + 7-metilksantin S-adenozil-L-homocistein + 3,7-dimetilksantin
Ovo je treći enzim u biosintezi kofeina. Enzim takođe može da katalizuje konverziju paraksantina u kofein.
Reference uredi
- ↑ Ogawa, M., Herai, Y., Koizumi, N., Kusano, T. and Sano, H. (2001). „7-Methylxanthine methyltransferase of coffee plants. Gene isolation and enzymatic properties”. J. Biol. Chem. 276: 8213-8218. PMID 11108716.
- ↑ Uefuji, H., Ogita, S., Yamaguchi, Y., Koizumi, N. and Sano, H. (2003). „Molecular cloning and functional characterization of three distinct N-methyltransferases involved in the caffeine biosynthetic pathway in coffee plants”. Plant Physiol. 132: 372-380. PMID 12746542.
- ↑ Yoneyama, N., Morimoto, H., Ye, C.X., Ashihara, H., Mizuno, K. and Kato, M. (2006). „Substrate specificity of N-methyltransferase involved in purine alkaloids synthesis is dependent upon one amino acid residue of the enzyme”. Mol. Genet. Genomics 275: 125-135. PMID 16333668.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.