Metanol—5-hidroksibenzimidazolilkobamid Co-metiltransferaza
(Preusmjereno sa stranice MT 1)
Metanol—5-hidroksibenzimidazolilkobamid Co-metiltransferaza (EC 2.1.1.90, metanol kobalaminska metiltransferaza, metanol:5-hidroksibenzimidazolilkobamidna metiltransferaza, MT 1 (nespecifična), metanol 5-hidroksibenzimidazolilkobamidna Co-metiltransferaza, mtaB (gen)) je enzim sa sistematskim imenom metanol:5-hidroksibenzimidazolilkobamid Co-metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Metanol—5-hidroksibenzimidazolilkobamid Co-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.90 | ||||||||
| CAS broj | 86611-98-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- metanol+ [Co(I) metanol-specifični korinoidni protein] [metil-Co(III) metanol-specifični korinoidni protein] + H2O
Enzim, koji katalizuje transfer metil grupa sa metanola na metanol-specifični korinoidni protein (MtaC), učestvuje u metanogenezi koristeći metanol.
Reference
uredi- ↑ van der Meijden, P., te Brömmelstroet, B.W., Poirot, C.M., van der Drift, C. and Vogels, G.D. (1984). „Purification and properties of methanol:5-hydroxybenzimidazolylcobamide methyltransferase from Methanosarcina barkeri”. J. Bacteriol. 160: 629-635. PMID 6438059.
- ↑ Sauer, K. and Thauer, R.K. (1999). „Methanol:coenzyme M methyltransferase from Methanosarcina barkeri – substitution of the corrinoid harbouring subunit MtaC by free cob(I)alamin”. Eur. J. Biochem. 261: 674-681. PMID 10215883.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.