IRNK (nukleozid-2'-O-)-metiltransferaza
(Preusmjereno sa stranice MRNA (nucleoside-2'-O)-methyltransferase)
iRNK (nukleozid-2'-O-)-metiltransferaza (EC 2.1.1.57, informacioni ribonukleatni nukleozid 2'-metiltransferaza, informacioni RNK (nukleozid-2'-)-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:iRNK (nukleozid-2'-O)-metiltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| iRNK (nukleozid-2'-O-)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.57 | ||||||||
| CAS broj | 61970-02-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozil-L-metionin + m7G5'ppp5'R-iRNK S-adenozil-L-homocistein + m7G5'ppp5'Rm-iRNK
Nukleozid pored terminalnog guanozina može da bude bilo guanozin ili adenozin. Formiranje 2'-O-metiladenozinske kape je ranije bilo klasifikovano kao EC 2.1.1.58.
Reference
uredi- ↑ Barbosa, E. and Moss, B. (1978). „mRNA(nucleoside-2′-)-methyltransferase from vaccinia virus. Purification and physical properties”. J. Biol. Chem. 253: 7692-7697. PMID 701281.
- ↑ Barbosa, E. and Moss, B. (1978). „mRNA(nucleoside-2′-)-methyltransferase from vaccinia virus. Characteristics and substrate specificity”. J. Biol. Chem. 253: 7698-7702. PMID 701282.
- ↑ Boone, R.F., Ensinger, M.J. and Moss, B. (1977). „Synthesis of mRNA guanylyltransferase and mRNA methyltransferases in cells infected with vaccinia virus”. J. Virol. 21: 475-483. PMID 833934.
- ↑ Ensinger, M.J., Martin, S.A., Paoletti, E. and Moss, B. (1975). „Modification of the 5′-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus”. Proc. Natl. Acad. Sci. USA 72: 2525-2529. PMID 1058472.
- ↑ Groner, Y., Gilbao, E. and Aviv, H. (1978). „Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates”. Biochemistry 17: 977-982. PMID 629955.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.