Protein višestrukog PDZ domena

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Protein višestrukog PDZ domena je protein koji je kod ljudi kodiran MPDZ genom.

Protein višestrukog PDZ domena
PDB prikaz baziran na 2fcf.
Dostupne strukture
2FCF, 2FNE, 2IWN, 2IWO, 2IWP, 2IWQ, 2O2T, 2OPG, 2QG1
Identifikatori
Simboli	MPDZ; MUPP1
Vanjski ID	OMIM: 603785 MGI: 1343489 HomoloGene: 2841 GeneCards: MPDZ Gene
Ontologija gena Molekularna funkcija • proteinsko vezivanje • vezivanje protein C-terminusa Celularna komponenta • citoplazma • postsinaptička gustina • apikalna ćelijska membran Biološki proces • ćelijska adhezija • virus-domaćin interacija
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	8777	17475
Ensembl	ENSG00000107186	ENSMUSG00000028402
UniProt	O75970	Q8VBX6
RefSeq (mRNA)	NM_001261406.1	NM_010820.2
RefSeq (protein)	NP_001248335.1	NP_034950.2
Lokacija (UCSC)	Chr 9: 13.11 - 13.28 Mb	Chr 4: 81.28 - 81.44 Mb
PubMed pretraga	[1]	[2]

Interakcije

MPDZ formira interakcije sa CD117, PLEKHA1 i 5-HT2C receptor.

Literatura

• Ullmer C, Schmuck K, Figge A, Lübbert H (1998). „Cloning and characterization of MUPP1, a novel PDZ domain protein”. FEBS Lett. 424 (1–2): 63–8. DOI:10.1016/S0014-5793(98)00141-0. PMID 9537516. 
• Barritt DS, Pearn MT, Zisch AH i dr.. (2000). „The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2”. J. Cell. Biochem. 79 (2): 213–24. DOI:10.1002/1097-4644(20001101)79:2<213::AID-JCB50>3.0.CO;2-G. PMID 10967549. 
• Lee SS, Glaunsinger B, Mantovani F i dr.. (2000). „Multi-PDZ Domain Protein MUPP1 Is a Cellular Target for both Adenovirus E4-ORF1 and High-Risk Papillomavirus Type 18 E6 Oncoproteins”. J. Virol. 74 (20): 9680–93. DOI:10.1128/JVI.74.20.9680-9693.2000. PMC 112400. PMID 11000240. 
• Mancini A, Koch A, Stefan M i dr.. (2000). „The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity”. FEBS Lett. 482 (1–2): 54–8. DOI:10.1016/S0014-5793(00)02036-6. PMID 11018522. 
• Becamel C, Figge A, Poliak S i dr.. (2001). „Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1”. J. Biol. Chem. 276 (16): 12974–82. DOI:10.1074/jbc.M008089200. PMID 11150294. 
• Vassilev A, Kaneko KJ, Shu H i dr.. (2001). „TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm”. Genes Dev. 15 (10): 1229–41. DOI:10.1101/gad.888601. PMC 313800. PMID 11358867. 
• Hamazaki Y, Itoh M, Sasaki H i dr.. (2002). „Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule”. J. Biol. Chem. 277 (1): 455–61. DOI:10.1074/jbc.M109005200. PMID 11689568. 
• Kimber WA, Trinkle-Mulcahy L, Cheung PC i dr.. (2002). „Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo”. Biochem. J. 361 (Pt 3): 525–36. DOI:10.1042/0264-6021:3610525. PMC 1222335. PMID 11802782. 
• Poliak S, Matlis S, Ullmer C i dr.. (2002). „Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells”. J. Cell Biol. 159 (2): 361–72. DOI:10.1083/jcb.200207050. PMC 2173042. PMID 12403818. 
• Griffon N, Jeanneteau F, Prieur F i dr.. (2003). „CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors”. Brain Res. Mol. Brain Res. 117 (1): 47–57. DOI:10.1016/S0169-328X(03)00283-3. PMID 14499480. 
• Ota T, Suzuki Y, Nishikawa T i dr.. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
• Humphray SJ, Oliver K, Hunt AR i dr.. (2004). „DNA sequence and analysis of human chromosome 9”. Nature 429 (6990): 369–74. DOI:10.1038/nature02465. PMC 2734081. PMID 15164053. 
• Krapivinsky G, Medina I, Krapivinsky L i dr.. (2004). „SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation”. Neuron 43 (4): 563–74. DOI:10.1016/j.neuron.2004.08.003. PMID 15312654. 
• van de Pavert SA (2005). „Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure”. J. Cell. Sci. 117 (Pt 18): 4169–77. DOI:10.1242/jcs.01301. PMID 15316081. 
• Coyne CB, Voelker T, Pichla SL, Bergelson JM (2005). „The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction”. J. Biol. Chem. 279 (46): 48079–84. DOI:10.1074/jbc.M409061200. PMID 15364909. 
• Okuhira K, Fitzgerald ML, Sarracino DA i dr.. (2006). „Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux”. J. Biol. Chem. 280 (47): 39653–64. DOI:10.1074/jbc.M510187200. PMID 16192269. 
• Heydecke D, Meyer D, Ackermann F i dr.. (2006). „The multi PDZ domain protein MUPP1 as a putative scaffolding protein for organizing signaling complexes in the acrosome of mammalian spermatozoa”. J. Androl. 27 (3): 390–404. DOI:10.2164/jandrol.05166. PMID 16452527. 
• Olsen JV, Blagoev B, Gnad F i dr.. (2006). „Global, in vivo, and site-specific phosphorylation dynamics in signaling networks”. Cell 127 (3): 635–48. DOI:10.1016/j.cell.2006.09.026. PMID 17081983. 
• Szafranski K, Schindler S, Taudien S i dr.. (2007). „Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns”. Genome Biology 8 (8): R154. DOI:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.