Stromelizin-1
(Preusmjereno sa stranice MMP-3)
Stromelizin-1 (EC 3.4.24.17, matriks metaloproteinaza 3, proteoglikanaza, kolagenaza aktivacinog protein, prokolagenazni aktivator, tranzin, MMP-3, neutralna proteoglikanaza, stromelizin, kolagen-aktivirajući protein) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Stromelizin-1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.17 | ||||||||
| CAS broj | 79955-99-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- Preferentno razlaganje na mestima gde su P1', P2' i P3' hidrofobni ostaci
Ova ekstracelularna endopeptidaza je prisutna u tkivu kičmenjaka.
Reference uredi
- ↑ Chin, J.R., Murphy, G. and Werb, Z. (1985). „Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates”. J. Biol. Chem. 260: 12367-12376. PMID 2995374.
- ↑ Okada, Y., Nagase, H. and Harris, E.D., Jr. (1986). „A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization”. J. Biol. Chem. 261: 14245-14255. PMID 3095317.
- ↑ Docherty, A.J.P. and Murphy, G. (1990). „The tissue metalloproteinase family and the inhibitor TIMP: a study using cDNAs and recombinant proteins”. Ann. Rheum. Dis. 49: 469-479. PMID 2197998.
- ↑ Emonard, H. and Grimaud, J.-A. (1990). „Matrix metalloproteinase. A review”. Cell. Mol. Biol. 36: 131-153. PMID 2165861.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.