2,5-diamino-6-(ribozilamino)-4(3H)-pirimidinon 5'-fosfat reduktaza
(Preusmjereno sa stranice MJ0671 (gene name))
2,5-diamino-6-(ribozilamino)-4(3H)-pirimidinon 5'-fosfat reduktaza (EC 1.1.1.302, 2,5-diamino-6-ribozilamino-4(3H)-pirimidinon 5'-fosfatna reduktaza, MjaRED, MJ0671 (gen)) je enzim sa sistematskim imenom 2,5-diamino-6-(5-fosfo-D-ribozilamino)pirimidin-4(3H)-on:NAD(P)+ oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 2,5-diamino-6-(ribozilamino)-4(3H)-pirimidinon 5'-fosfat reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.302 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- 2,5-diamino-6-(5-fosfo-D-ribitilamino)pirimidin-4(3H)-on + NAD(P)+ 2,5-diamino-6-(5-fosfo-D-ribozilamino)pirimidin-4(3H)-on + NAD(P)H + H+
Reakcija teče u suprotnom smeru. Dejstvo ovog enzima je korak u riboflavinskoj biosintezi. NADPH i NADH funkcionišu jednako dobro kao reduktanti. Ovaj enzim se razlikuje od EC 1.1.1.193, 5-amino-6-(5-fosforibozilamino)uracil reduktaze, pošto on ne katalizuje redukciju 5-amino-6-ribozilaminopirimidin-2,4(1H,3H)-dion 5'-fosfata.
Reference uredi
- ↑ Graupner, M., Xu, H. and White, R.H. (2002). „The pyrimidine nucleotide reductase step in riboflavin and F420 biosynthesis in archaea proceeds by the eukaryotic route to riboflavin”. J. Bacteriol. 184: 1952-1957. PMID 11889103.
- ↑ Chatwell, L., Krojer, T., Fidler, A., Romisch, W., Eisenreich, W., Bacher, A., Huber, R. and Fischer, M. (2006). „Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5′-phosphate reductase of Methanocaldococcus jannaschii”. J. Mol. Biol. 359: 1334-1351. PMID 16730025.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.