2-C-metil-D-eritritol 4-fosfat citidililtransferaza
(Preusmjereno sa stranice MEP citidililtransferaza)
2-C-metil-D-eritritol 4-fosfat citidililtransferaza (EC 2.7.7.60, MEP citidililtransferaza) je enzim sa sistematskim imenom CTP:2-C-metil-D-eritritol 4-fosfat citidililtransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
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| Identifikatori | |||||||||
| EC broj | 2.7.7.60 | ||||||||
| CAS broj | 251990-59-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- CTP + 2-C-metil-D-eritritol 4-fosfat difosfat + 4-(citidin 5'-difosfo)-2-C-metil-D-eritritol
Za rad enzim iz Escherichia coli je neophodan jon Mg2+ ili Mn2+.
Reference uredi
- ↑ Rohdich, F., Wungsintaweekul, J., Fellermeier, M., Sagner, S., Herz, S., Kis, K., Eisenreich, W., Bacher, A. and Zenk, M.H. (1999). „Cytidine 5′-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erithritol”. Proc. Natl Acad. Sci. USA 96: 11758-11763. PMID 10518523.
- ↑ Kuzuyama, T., Takagi, M., Kaneda, K., Dairi, T. and Seto, H. (2000). „Formation of 4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol from 2-C-methyl-D-erythritol 4-phosphate by 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, a new enzyme in the nonmevalonate pathway”. Tetrahedron Lett. 41: 703-706.
Literatura uredi
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.