MAP kinaza kinaza kinaza
MAP kinaza kinaza kinaza (EC 2.7.11.25, cMos, cRaf, MAPKKK, MAP3K, MEKK, MEKK1, MEKK2, MEKK3, MEK kinaza, Mil/Raf, MLK-slična mitogen-aktivirajuća proteinska trostruka kinaza, MLTK, MLTKa, MLTKb, REKS, STK28) je enzim sa sistematskim imenom ATP:protein fosfotransferaza (MAPKKKK-activated).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| MAP kinaza kinaza kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.11.25 | ||||||||
| CAS broj | 146702-84-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ATP + protein ADP + fosfoprotein
Ovaj enzim fosforiliše i aktivira proteinsku kinazu, EC 2.7.12.2, mitogen-aktiviranu proteinsku kinazu kinazu (MAPKK). Za njegovo dejstvo je neophodna MAPKKK.
Reference
uredi- ↑ Wang, X.S., Diener, K., Jannuzzi, D., Trollinger, D., Tan, T.H., Lichenstein, H., Zukowski, M. and Yao, Z. (1996). „Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase”. J. Biol. Chem. 271: 31607-31611. PMID 8940179.
- ↑ Gotoh, I., Adachi, M. and Nishida, E. Identification and characterization of a novel MAP kinase kinase kinase, MLTK. (2001). „J”. Biol. Chem. 276: 4276-4286. PMID 11042189.
- ↑ Vojtek, A.B., Hollenberg, S.M. and Cooper, J.A. (1993). „Mammalian Ras interacts directly with the serine/threonine kinase Raf”. Cell 74: 205-214. PMID 8334704.
Literatura
uredi- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.