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MAP3K14 (Mitogenom-aktivirana protein kinaza kinaza kinaza 14, NF-kapa-B-indukujuća kinaza, NIK), je enzim koji je kod čoveka kodiran MAP3K14 genom.[1][2]

Mitogenom-aktivirana protein kinaza kinaza kinaza 14
Identifikatori
SimboliMAP3K14; FTDCR1B; HS; HSNIK; NIK
Vanjski IDOMIM604655 MGI1858204 HomoloGene2940 GeneCards: MAP3K14 Gene
EC broj2.7.11.25
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez902053859
EnsemblENSG00000006062ENSMUSG00000020941
UniProtQ99558Q544K4
RefSeq (mRNA)NM_003954NM_016896
RefSeq (protein)NP_003945NP_058592
Lokacija (UCSC)Chr 17:
40.7 - 40.75 Mb
Chr 11:
103.04 - 103.08 Mb
PubMed pretraga[1][2]

Funkcija

uredi

Ovaj gen kodira mitogenom-activiranu kinaza kinaza kinazu 14, koja je serin/treonin-specifična proteinska kinaza. Ova kinaza se vezuje za TRAF2 i stimuliše NF-κB aktivnost. Ona je kritična kinaza alternativnog NF-κB aktivacionog puta. Njena sekvenca je slična sa nekoliko drugih MAPKK kinaza. Ona učestvuje u NF-κB-indukovanoj signalnoj kaskadi koja je zajednička za receptore TNF/NGF) familije i za interleukinski-1 tip-I receptor.[2]

Interakcije

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Za MAP3K14 je pokazano da interaguje sa TRAF2,[3][4] IKK2[3][5] i CHUK.[6][7][3][8]

Literatura

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  1. Malinin NL, Boldin MP, Kovalenko AV, Wallach D (Mar 1997). „MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1”. Nature 385 (6616): 540–4. DOI:10.1038/385540a0. PMID 9020361. 
  2. Vrati se na: 2,0 2,1 „Entrez Gene: MAP3K14 mitogen-activated protein kinase kinase kinase 14”. 
  3. Vrati se na: 3,0 3,1 3,2 Luftig, M A; Cahir-McFarland E, Mosialos G, Kieff E (May 2001). „Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40”. J. Biol. Chem. (United States) 276 (18): 14602–6. DOI:10.1074/jbc.C100103200. ISSN 0021-9258. PMID 11278268. 
  4. Malinin, N L; Boldin M P, Kovalenko A V, Wallach D (February 1997). „MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1”. Nature (ENGLAND) 385 (6616): 540–4. DOI:10.1038/385540a0. ISSN 0028-0836. PMID 9020361. 
  5. Woronicz, J D; Gao X, Cao Z, Rothe M, Goeddel D V (October 1997). „IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK”. Science (UNITED STATES) 278 (5339): 866–9. DOI:10.1126/science.278.5339.866. ISSN 0036-8075. PMID 9346485. 
  6. Régnier, C H; Song H Y, Gao X, Goeddel D V, Cao Z, Rothe M (July 1997). „Identification and characterization of an IkappaB kinase”. Cell (UNITED STATES) 90 (2): 373–83. DOI:10.1016/S0092-8674(00)80344-X. ISSN 0092-8674. PMID 9244310. 
  7. Xiao, G; Sun S C (July 2000). „Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain”. J. Biol. Chem. (UNITED STATES) 275 (28): 21081–5. DOI:10.1074/jbc.M002552200. ISSN 0021-9258. PMID 10887201. 
  8. Ninomiya-Tsuji, J; Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K (March 1999). „The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway”. Nature (ENGLAND) 398 (6724): 252–6. DOI:10.1038/18465. ISSN 0028-0836. PMID 10094049. 

Dodatna literatura

uredi